District Health Information Systems 2 (DHIS2) has provided a major leap forward in communication and management of health services. The sole purpose of this study is to discuss the effectiveness of DHIS2 in Garissa County since the year 2013. This study clearly defines DHIS2 by giving its relevance, importance and how it has impacted the management of health records in Garissa county. The methodology adopted in the research involves obtaining the cross health record of the whole county from the District Health Information System database from the year 2013 to 2017. This entails the records of all the health facilities in the county, ranging from dispensaries, clinics, hospitals up to the county referral hospital. The data is cross tabulation of patients, diseases, deaths and other health related records. The findings from the research are then represented graphically showing overall trend over the period under consideration. The data is analysed using mathematical and statistical models and approaches. Interpretations are then made based on the analysis and represented graphically in systematic manner, giving a clear indication of the reality. Conclusions are made based on the observation from the analysis. The recommendations are hence given to The Ministry of Health in Garissa county. This entails measures to counter various diseases and assignment of health officers based on attacks of respective diseases for proper management of the diseases and also for balance of resources for the purpose of policy making.