Abstract There are various diseases affecting the residents of Homabay County. The infant and maternal deaths have been observed over a period of years. The general objective was to determine the occurrence of various diseases, infants and maternal deaths in Homa Bay County. Raw data was given to facilitate the project. Data analysis was done using R and was mainly descriptive. Correlation between variables was obtained. Various charts were also illustrated. According to the data, the occurrence of various, infant and maternal deaths were found to be distributed over the four years under study. Malaria cases were the highest while yellow fever case was only one. It was also noticed that not many pregnant women attend scheduled antenatal care. Maternal deaths have increased in 2017 as compared to 2014.