Analysis Of Pharmacokinetic Data
The aim is to explore how the package, PK, is used in analyzing pharmacokinetic
data. In the process we ï¬nd the peak concentrations ( C max) , peak time (
T max) , terminal half-life ( t 1/2) and area under the curve ( AUC).The peak
time and the peak concentration are obtained directly from the observations.
The terminal half-life is used to describe the decay of drug concentration in the
terminal phase while area under the curve is used to measure the amount of
drug absorbed or the efficiency of physiological processes that characterize the
drug elimination [1].
Data is also described by interpolating or extrapolating with functions such as
monoexponential, biexponential or multiexponential models .They are used to
reduce data into a small set of parameters or test if the hypothesis incorporated
in the function is fulï¬lled by the observed values. By changing the amount of
the drug its properties can be observed by assessing the corresponding values of
area under the concentration versus time graph and other parameters.